Spiro-oxindole compounds and their uses as therapeutic agents

This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodru...

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Main Authors SUN, JIANYU, FU, JIANMIN, CHOWDHURY, SULTAN, RAINA, VANDNA, FRASER, ROBERT, CHAKKA, NAGASREE, KAMBOJ, RAJENDER K, SVIRIDOV, SERGUEI, HOU, DUANJIE, LIU, SHIFENG, BAGHERZADEH, MEHRAN SEID, CHAFEEV, MIKHAIL, HSIEH, TOM, SUN, SHAOYI
Format Patent
LanguageEnglish
French
German
Published 07.05.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R 1 , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b , R 3c , and R 3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
Bibliography:Application Number: EP20110009687