NOVEL CRYSTAL FORMS OF TRICYCLIC BENZOPYRAN COMPOUND AND PROCESSES FOR PRODUCING SAME

[PROBLEMS TO BE SOLVED] To provide crystal forms of (3R, 4S)-7-hydroxymethyl-2,2,9-trimethyl-4-(phenethylamino)-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol that are excellent as a drug, and production methods thereof. [MEANS FOR SOLVING THE PROBLEMS] Production methods including crystallizing (3R, 4S)...

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Bibliographic Details
Main Authors UMEDA, YASUHIRO, KAWAHARA, SHIRO, TAKADA, YASUTAKA, KAMON, MIYAKO
Format Patent
LanguageEnglish
French
German
Published 07.03.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:[PROBLEMS TO BE SOLVED] To provide crystal forms of (3R, 4S)-7-hydroxymethyl-2,2,9-trimethyl-4-(phenethylamino)-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol that are excellent as a drug, and production methods thereof. [MEANS FOR SOLVING THE PROBLEMS] Production methods including crystallizing (3R, 4S)-7-hydroxymethyl-2,2,9-trimethyl-4-(phenethylamino)-3,4-dlhydro-2H-pyrano[2,3-g]quinolin-3-ol from an acetate ester solvent, an aliphatic hydrocarbon solvent, a nitrile solvent, an aromatic hydrocarbon solvent, a ketone solvent or an ether solvent, and crystal forms obtained according to the methods.
Bibliography:Application Number: EP20100769836