A HUMAN ANTI-TUMOR NECROSIS FACTOR ALPHA MONOCLONAL ANTIBODY AND USE THEREOF

A protein capable of specifically binding to human TNF± (tumor necrosis factor alpha) is provided, i.e. human anti-TNF± monoclonal antibody derived from human B cells. The light and heavy chains of the antibody comprise the amino acid sequences as shown in SEQ ID NO: 8 and SEQ ID NO: 9 or 10, respec...

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Bibliographic Details
Main Author LIU, QINGFA
Format Patent
LanguageEnglish
French
German
Published 08.08.2012
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:A protein capable of specifically binding to human TNF± (tumor necrosis factor alpha) is provided, i.e. human anti-TNF± monoclonal antibody derived from human B cells. The light and heavy chains of the antibody comprise the amino acid sequences as shown in SEQ ID NO: 8 and SEQ ID NO: 9 or 10, respectively. The encoding gene, the Fab antibody and the use in the preparation of the medicament for treating TNF±-related inflammation of the anti-TNF± antibody are also provided.
Bibliography:Application Number: EP20090841729