Method for hydrophilizing surfaces of fluid components and objects containing such components

• Main Authors: HOFMANN, WOLFGANG, NOORMOFIDI, TAGHI, ZAHRL, DORIS
• Format: Patent
• Language: English; French; German
• Published: 25.01.2012
• Subjects: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; TRANSPORTING

Partial configuration of the inner surfaces of the fluidic components, preferably a measuring channel (5) comprising at least one sensor element, a sensor cassette (4) with a hydrophilic polymer, insertable interchangeably into an analyzer (1), comprises (a) inserting the sensor cassette into the analyzer, (b) introducing an aqueous solution of hydrophilic polyaminosaccharide into the measuring channel of the sensor cassette, and (c) replacing the aqueous solution of polyaminosaccharide after a residence time by a gaseous or a liquid medium. Partial configuration of the inner surfaces of the fluidic components, preferably a measuring channel (5) comprising at least one sensor element, a sensor cassette (4) with a hydrophilic polymer, insertable interchangeably into an analyzer (1), comprises (a) inserting the sensor cassette into the analyzer, (b) introducing an aqueous solution of hydrophilic polyaminosaccharide into the measuring channel of the sensor cassette, and (c) replacing the aqueous solution of polyaminosaccharide after a residence time by a gaseous or a liquid medium, where residues of polyaminosaccharide remains on the inner surface of the measuring channel and the surface is hydrophilized. Independent claims are also included for: (1) the sensor cassette, which is interchangeably insertable in the analyzer, where its inner surfaces of the fluidic components, preferably the measuring channel with at least one sensor element, is at least partially covered with the hydrophilic polymer, and the inner surfaces exhibits an island like or complete-surface covering, which comprises or is made from chitosan; and (2) a fluid Pack (2), which is insertable in the analyzer, comprising many containers for holding washing-, calibration- and/or quality control-fluids for the analyzer, where the washing-, calibration- and/or quality control-fluid additionally comprises chitosan, or a second container for holding a preferably physiological chitosan. Die Erfindung betrifft ein Verfahren zur zumindest teilweisen Belegung der inneren Oberflächen von fluidischen Komponenten, insbesondere eines zumindest ein Sensorelement aufweisenden Messkanals, einer in einen Analysator austauschbar einsetzbaren Sensorkassette mit einem hydrophilen Polymer. Das Verfahren ist dadurch gekennzeichnet dass eine ungebrauchte Sensorkassette in den Analysator eingesetzt wird, dass eine wässrige Lösung eines hydrophilen Polyaminosaccharids (vorzugsweise Chitosan) in den Messkanal der Sensorkassette eingeleitet wird, sowie dass die wässrige Lösung des Polyaminosaccharids nach einer Verweilzeit durch ein gasförmiges oder flüssiges Medium ersetzt wird, wobei Reste des Polyaminosaccharids auf der inneren Oberfläche des Messkanals verbleiben und diese hydrophilisieren.