INHIBITORS OF AKT ACTIVITY

The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibi...

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Main Authors SAKAMOTO, TOSHIHIRO, LEE, SHULIANG, SIU, TONY, KAWANISHI, NOBUHIKO, PANDI, BHARATHI, PEEL, MICHAEL, R, OGINO, YOSHIO, LIU, HAO, ONOZAKI, YU, HAXELL, THOMAS, F. N, JENKS, MATTHEW, G, FAN, WEIMING, MOORE, JOSEPH, A., III, MALASKA, MICHAEL, J
Format Patent
LanguageEnglish
French
German
Published 21.11.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
Bibliography:Application Number: EP20100751342