Methods using an osteopenia animal model

The present invention provides a method for producing an osteopenia animal model by RANKL administration and an osteopenia animal model. Also, a method for producing an osteopenia animal model, comprising administering, soluble RANKL or a fused protein of soluble RANKL with an epitope tag to a non-h...

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Bibliographic Details
Main Authors TOMIMORI, YOSHIYA, YASUDA, HISATAKA
Format Patent
LanguageEnglish
French
German
Published 30.11.2011
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
NEW BREEDS OF ANIMALS
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TESTING
TRAPPING
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Summary:The present invention provides a method for producing an osteopenia animal model by RANKL administration and an osteopenia animal model. Also, a method for producing an osteopenia animal model, comprising administering, soluble RANKL or a fused protein of soluble RANKL with an epitope tag to a non-human animal so as to promote in vivo osteoclast differentiation and activation in the non-human animal, and an osteopenia animal model produced by the method are provided.
Bibliography:Application Number: EP20110169483