A process for preparing a substituted oxazole

A process for producing a compound of formula ID: where R 1 is haloalkyl, R 2 and R 4 are alkyl, R 5 is generally hydrogen or alkyl and R 6 is an acid labile group, by reacting a compound containing a substituent -C(R 3 X)NCH 2 C(O)OR 4 , where R 3 is hydrogen or alkyl and X is O or S, with an alkal...

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Main Authors CUTARELLI, TIMOTHY, D, YIN, JIANGUO, ZHANG, SHUYI, FU, XIAOYONG, REEDER, MICHAEL, R, MCALLISTER, TIMOTHY, L, YONG, KELVIN, H
Format Patent
LanguageEnglish
French
German
Published 09.11.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for producing a compound of formula ID: where R 1 is haloalkyl, R 2 and R 4 are alkyl, R 5 is generally hydrogen or alkyl and R 6 is an acid labile group, by reacting a compound containing a substituent -C(R 3 X)NCH 2 C(O)OR 4 , where R 3 is hydrogen or alkyl and X is O or S, with an alkali metal amide base and a compound R 6 NHCH(R 5 )C(O)R 7 where R 7 is an activated acid moiety.
Bibliography:Application Number: EP20110173798