3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine or Isoquinolone and having the formula (I): wherein S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compoun...

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Bibliographic Details
Main Authors MACKAY, D. BRUCE, MACDONALD, DWIGHT, CHEN, AUSTIN CHIH-YU, FOURNIER, PIERRE-ANDRE, WU, TOM YAO-HSIANG, DUBE, DANIEL, LALIBERTE, SEBASTIEN, MCKAY, DANIEL JAMES, LACOMBE, PATRICK, GRIMM, ERICH, L
Format Patent
LanguageEnglish
French
German
Published 19.10.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine or Isoquinolone and having the formula (I): wherein S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
Bibliography:Application Number: EP20090831337