Peptides and their derived type APL of the HSP60 and pharmaceutical compositions

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of...

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Main Authors LORENZO PEREZ, NORAILYS, MORERA CORDOVA, VIVIAN, DOMINGUEZ HORTA, MARIA DEL CARMEN, PADRON PALOMARES, GABRIEL RAMON, LOPEZ MARIN, NELIA, COSME DIAZ, CARELIA, MERINO GARCIA, NELSON J, HERNANDEZ GARCIA, ARIADNA, VASQUEZ BONACHEA, ARIEL, BARBERA BETANCOURT, ARIANA, SUAREZ ALBA, JOSE
Format Patent
LanguageEnglish
French
German
Published 05.10.2011
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
Bibliography:Application Number: EP20100189769