VACCINE COMPRISING PROTEIN NMBO964 FROM MEISSERIA MENINGITIDIS

The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and t...

Full description

Saved in:
Bibliographic Details
Main Authors WEYNANTS, VINCENT, BOS, MARTINE PETRONELLA, POOLMAN, JAN, STORK, MICHIEL, TOMMASSEN, JOHANNES PETRUS MARIA
Format Patent
LanguageEnglish
French
German
Published 15.06.2011
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.
Bibliography:Application Number: EP20090779121