DIARYL COMPOUNDS AND USES THEREOF

The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X6 are as defined herein. The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid receptors (KORs). Specifically, the compounds are selective anta...

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Bibliographic Details
Main Authors MCLEAN, STAFFORD, MCHARDY, STANTON, FURST, PARIKH, VINOD, DIPAK, HAYWARD, MATTHEW, MERRILL, VERHOEST, PATRICK, ROBERT
Format Patent
LanguageEnglish
French
German
Published 18.05.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X6 are as defined herein. The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid receptors (KORs). Specifically, the compounds are selective antagonists of KORs and are highly selective to KORs relative to mu and delta opioid receptors.
Bibliography:Application Number: EP20090769699