IMPROVEMENTS TO MASS SPECTROMETRY

Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) apparatus and method comprising a laser and a multimode optical fiber to deliver a laser beam to a MADLI ion source. A vibration coupling is provided at a region along the length of optical fiber to impart an oscillato...

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Bibliographic Details
Main Authors CLENCH, MALCOLM, ATKINSON, SALLY, OAKES, KEITH
Format Patent
LanguageEnglish
French
German
Published 23.03.2011
Subjects
BASIC ELECTRIC ELEMENTS
ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
ELECTRICITY
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Summary:Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) apparatus and method comprising a laser and a multimode optical fiber to deliver a laser beam to a MADLI ion source. A vibration coupling is provided at a region along the length of optical fiber to impart an oscillatory vibrational motion at the optical fibre to move the irradiation intensity maxima at the sample to increase the effective irradiation surface area. The present apparatus and method provide increased imaging sensitivity and a corresponding reduction in data acquisition times.
Bibliography:Application Number: EP20090754132