Compositions and methods for use in tergeting vascular destruction

• Main Authors: PETTIT, GEORGE R, LIPPERT, JOHN W
• Format: Patent
• Language: English; French; German
• Published: 05.10.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention is directed to compounds of Formula I: wherein X represents cis - or trans- alkenyl group represented by -(CH=CH) 1 -; each of R 1 , R 2 , R 3 and R 4 is H or Q + , while at least one of R 1 , R 2 , R 3 and R 4 is Q + ; and Q + is a sodium, piperazine, or nicotinamide cation. The invention also relates to pharmaceutical compositions comprising these compounds. The compounds of the invention can be used for the treatment of neoplastic disease.