2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders

Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n' is selected from 1,2 and 3; R' 1 is selected from phenyl, pyri...

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Main Authors KARANEWSKY, DONALD, ZHANG, QIONG, WAN, YONGQIN, MIYAKE, TAKAHIRO, JIANG, JIQING, KAWAHARA, EIJI, KANAZAWA, TAKANORI, DING, QIANG, GARCIA-ECHEVERRIA, CARLOS, GRAY, NATHANAEL, SCHIANDER, CHOPIUK, GREG, OHMORI, OSAMU, STEENSMA, RUO, MASUYA, KEIICHI, MATSUURA, NAOKO, UMEMURA, ICHIRO
Format Patent
LanguageEnglish
French
German
Published 29.05.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n' is selected from 1,2 and 3; R' 1 is selected from phenyl, pyridinyl, pyrazolyl and pyrimidinyl; and R' 2 and R' 3 are as described herein.
Bibliography:Application Number: EP20100010291