PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

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Main Authors REYNOLDS, MARK, E, SAVAGE, SCOTT, J, DINA, MICHAEL, S, CASTANEDO, GEORGETTE, SUTHERLIN, DANIEL, P, BAO, LIANG, LALONDE, REBECCA, L, GUNZNER, JANET, L, WANG, SHUMEI, STANLEY, MARK, S, MALESKY, KIMBERLY
Format Patent
LanguageEnglish
French
German
Published 12.01.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
AbstractList The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
Author SUTHERLIN, DANIEL, P
BAO, LIANG
CASTANEDO, GEORGETTE
LALONDE, REBECCA, L
GUNZNER, JANET, L
SAVAGE, SCOTT, J
STANLEY, MARK, S
REYNOLDS, MARK, E
MALESKY, KIMBERLY
WANG, SHUMEI
DINA, MICHAEL, S
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– fullname: BAO, LIANG
– fullname: LALONDE, REBECCA, L
– fullname: GUNZNER, JANET, L
– fullname: WANG, SHUMEI
– fullname: STANLEY, MARK, S
– fullname: MALESKY, KIMBERLY
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DocumentTitleAlternate PYRIDYLHEMMER DES HEDGEHOG-SIGNALWEGES
INHIBITEURS PYRIDILES DE SIGNALISATION HEDGEHOG
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Snippet The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
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