MODIFIED CPN10 AND PRR SIGNALLING

The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to composit...

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Main Authors LAMBERT, DANIEL, SCOTT, VAN HEUMEN, WALTER, RENE, ANTONIUS, HOWARD, CHRISTOPHER BRUCE, RALSTON, KYLIE, JANE, BROWN, RICHARD, JAMES, JAMES, ANDREW, LEIGH, STOK, JEANETTE, ELIZABETH, NAYLOR, DEAN, JASON, DE BAKKER, CHRISTOPHER JOHN, WARD, LINDA, ALISSON
Format Patent
LanguageEnglish
French
German
Published 20.02.2013
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Summary:The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
Bibliography:Application Number: EP20090730646