PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, o...

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Main Authors FENG, BAINIAN, GUNZNER, JANET, MORENO, DAVID, LUNGHOFER, PAUL, YOUNG, WENDY B, REN, LI, MALESKY, KIM, BUCKMELTER, ALEXANDRE J, RUDOLPH, JOACHIM, GRINA, JONAS, AHRENDT, KATERI A, DE MEESE, JASON, SEO, JEONGBEOB, WENGLOWSKY, STEVEN MARK, MATHIEU, SIMON, WEN, ZHAOYANG, LAIRD, ELLEN R, NEWHOUSE, BRAD, HANSEN, JOSHUA D, TIAN, HONGQI
Format Patent
LanguageEnglish
French
German
Published 29.12.2010
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Bibliography:Application Number: EP20090718306