ANTIBIOTIC TETRAHYDRO-BETA-CARBOLINE DERIVATIVES

Disclosed are compounds of Formula (I), pharmaceutical compositions comprising Formula (I) and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacter...

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Bibliographic Details
Main Author FRECHETTE, ROGER
Format Patent
LanguageEnglish
French
German
Published 20.10.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are compounds of Formula (I), pharmaceutical compositions comprising Formula (I) and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like.
Bibliography:Application Number: EP20080872407