Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection

• Main Authors: HOISETH, SUSAN K, PEEK, JOEL A, ZAGURSKY, ROBERT JOHN, METCALF, BENJAMIN J, GRIFFAIS, REMY, FLETCHER, LEAH DIANE, SANKARAN, BANUMATHI
• Format: Patent
• Language: English; French; German
• Published: 15.09.2010
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to an isolated polynucleotide having a nucleotide sequence of an open reading frame (ORF) of a Chlamydia trachomatis genome, comprising: (a) the nucleotide sequence of ORF693; (b) a nucleotide sequence exhibiting at least 99.9% identity with ORF693 : or (c) a nucleotide sequence exhibiting at least 80% homology to ORF693; or (d) a nucleotide sequence which hybridizes to ORF693 under conditions of high stringency (e) a fragment of any one of (a) to (d) which is greater than 20 nucleotides in length.