METHOD FOR PRODUCING OPTICALLY ACTIVE, RACEMIC MENTHOL

The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensiv...

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Bibliographic Details
Main Authors SCHMIDT-LEITHOFF, Joachim, KASHANI-SHIRAZI, Nawid, HEYDRICH, Gunnar, GRALLA, Gabriele, PACIELLO, Rocco, BERGNER, Eike Johannes, RAULS, Matthias, OEHLENSCHLÄGER, Steffen, EBEL, Klaus, KRAUSE, Wolfgang, FRIEDRICH, Marko, JÄKEL, Christoph
Format Patent
LanguageEnglish
French
German
Published 03.05.2017
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a particularly economic overall method for producing menthol, specifically for producing optically active, essentially enantiomerically and diastereomerically pure L-menthol and racemic menthol, starting from the starting material citral which is available inexpensively on an industrial scale. The method comprises the following steps a) catalytic hydrogenation of neral and/or geranial to give citronellal, b) cyclization of citronellal to isopulegol in the presence of an acidic catalyst, c) purification of isopulegol by crystallization and d) catalytic hydrogenation of isopulegol to give menthol.
Bibliography:Application Number: EP20080854428