NEW CRYSTALLINE DIPHENYL ACETIDINONE HYDRATE, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUND AND USE THEREOF

Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form (I), is new. Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydr...

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Bibliographic Details
Main Authors WOLLMANN, THEODOR ANDREAS, CULLMANN, FRANK, DUFFY, REGINA
Format Patent
LanguageEnglish
French
German
Published 25.08.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form (I), is new. Crystalline dodecanedioic acid 4-[(2S,3R)-3-[(S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzylamide ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-hexyl)-amide (A) in hydrate form of formula (I), is new. n : 0.5-1.8, preferably 1-1.2. Independent claims are included for: (1) a medicament comprising (I); and (2) the preparation of (I). [Image] ACTIVITY : Antilipemic. MECHANISM OF ACTION : None given.
Bibliography:Application Number: EP20080850642