INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mix...

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Main Authors MACHAALANI, ROGER, SMIL, DAVID, DEZIEL, ROBERT, BEAULIEU, PATRICK, MORADEI, OSCAR, AJAMIAN, ALAIN, TESSIER, PIERRE, FRECHETTE, SYLVIE, LEIT, SILVANA, MALLAIS, TAMMY, MANCUSO, JOHN
Format Patent
LanguageEnglish
French
German
Published 18.08.2010
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.
Bibliography:Application Number: EP20080845130