FLUORINATED DIHYDROTETRABENAZINE ETHER IMAGING AGENTS AND PROBES

The present invention provides novel fluorinated ether compounds related to dihydrotetrabenazine and intermediates useful in the preparation of such fluorinated ether compounds. The fluorinated ether compounds are provided in both racemic and enantiomerically enriched forms and may comprise either o...

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Bibliographic Details
Main Authors JOHNSON, BRUCE FLETCHER, RISHEL, MICHAEL JAMES, AMARASINGHE, KANDE KANKANANAMALAGE DAYARATHNA, DINN, SEAN RICHARD
Format Patent
LanguageEnglish
French
German
Published 11.08.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides novel fluorinated ether compounds related to dihydrotetrabenazine and intermediates useful in the preparation of such fluorinated ether compounds. The fluorinated ether compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The fluorinated ether compounds are shown to possess high affinity for VMAT-2, a biomarker implicated inter alia in human diabetes. The fluorinated ether compounds comprising a fluorine-18 group are useful as PET imaging agents targeting the VMAT-2 biomarker. The non-radiolabeled fluorinated ether compounds are useful as probes for the discovery of PET imaging agents.
Bibliography:Application Number: EP20080843128