N-TERMINAL MODIFIED INTERFERON-ALPHA

A method of reducing formation of non-natural disulfide bonds in a mature IFN-α by adding one or more amino acid residues to its N-terminus cystein. Also disclosed herein is the IFN-α thus modified.

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Bibliographic Details
Main Authors WU, BRYAN T. H, HSU, MING-PIN, SHEN, TSAI-KUEI, TENG, CHING-LEOU
Format Patent
LanguageEnglish
French
German
Published 25.12.2013
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
SUGARS
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Summary:A method of reducing formation of non-natural disulfide bonds in a mature IFN-α by adding one or more amino acid residues to its N-terminus cystein. Also disclosed herein is the IFN-α thus modified.
Bibliography:Application Number: EP20080835587