DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS

The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed...

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Main Authors HUDSON, RYAN, CHOI, SEOK-KI, GENDRON, ROLAND, MCMURTRIE, DARREN, FATHEREE, PAUL, R, MCKINNELL, ROBERT, MURRAY, JENDZA, KEITH, ALLEGRETTI, PAUL, OLSON, BROOKE
Format Patent
LanguageEnglish
French
German
Published 17.03.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
AbstractList The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Author GENDRON, ROLAND
MCMURTRIE, DARREN
CHOI, SEOK-KI
HUDSON, RYAN
OLSON, BROOKE
JENDZA, KEITH
FATHEREE, PAUL, R
ALLEGRETTI, PAUL
MCKINNELL, ROBERT, MURRAY
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– fullname: CHOI, SEOK-KI
– fullname: GENDRON, ROLAND
– fullname: MCMURTRIE, DARREN
– fullname: FATHEREE, PAUL, R
– fullname: MCKINNELL, ROBERT, MURRAY
– fullname: JENDZA, KEITH
– fullname: ALLEGRETTI, PAUL
– fullname: OLSON, BROOKE
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DocumentTitleAlternate DOPPELTWIRKENDE BLUTDRUCKSENKENDE BENZOIMIDAZOLMITTEL
AGENTS ANTIHYPERTENSEURS DE BENZIMIDAZOLE À DOUBLE EFFET
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Snippet The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS
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