DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS

The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed...

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Bibliographic Details
Main Authors HUDSON, RYAN, CHOI, SEOK-KI, GENDRON, ROLAND, MCMURTRIE, DARREN, FATHEREE, PAUL, R, MCKINNELL, ROBERT, MURRAY, JENDZA, KEITH, ALLEGRETTI, PAUL, OLSON, BROOKE
Format Patent
LanguageEnglish
French
German
Published 17.03.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Bibliography:Application Number: EP20080768064