2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently -C(H) or -N , provided that at least one of A and B is -N , n is 1-3, m is 0-3, and R1-4 are as def...

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Main Authors FILLA, SANDRA, ANN, COHEN, MICHAEL, PHILIP, GALLAGHER, PETER, THADDEUS, PINEIRO-NUNEZ, MARTA, MARIA, SPINAZZE, PATRICK, GIANPIETRO, WHATTON, MARIA, ANN, MAZANETZ, MICHAEL, PHILIP, CLARK, BARRY, PETER, CAMP, ANNE, MARIE, HELLMAN, SARAH, LYNNE, BADESCU, VALENTINA, O, SCHAUS, JOHN, MEHNERT
Format Patent
LanguageEnglish
French
German
Published 24.10.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently -C(H) or -N , provided that at least one of A and B is -N , n is 1-3, m is 0-3, and R1-4 are as defined herein.
Bibliography:Application Number: EP20080747748