MULTIMERIC CONJUGATE

The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have reduced immunogenicity as well as longer life time in vivo and an increased affinity compared to the unmodified biolog...

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Main Authors HEY, THOMAS, FIEDLER, ERIK, KRAEHMER, RALF, FIEDLER, ULRIKE, FIEDLER, MARKUS, LEENDERS, FRANK
Format Patent
LanguageEnglish
French
German
Published 21.10.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have reduced immunogenicity as well as longer life time in vivo and an increased affinity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
Bibliography:Application Number: EP20080708856