DARUSENTAN ORAL DOSAGE FORM
A solid discrete orally deliverable pharmaceutical dosage form comprises darusentan and one or more pharmaceutically acceptable excipients; wherein (a) the darusentan is in solid particulate form having a mean particle size of about 5 to about 200 mum and is present in the dosage form in an amount o...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
12.08.2009
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Subjects | |
Online Access | Get full text |
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Summary: | A solid discrete orally deliverable pharmaceutical dosage form comprises darusentan and one or more pharmaceutically acceptable excipients; wherein (a) the darusentan is in solid particulate form having a mean particle size of about 5 to about 200 mum and is present in the dosage form in an amount of about 1 to about 600 mg; and (b) the dosage form exhibits at least about 90% dissolution of the darusentan in 30 minutes in a standard in vitro dissolution test. A method for lowering blood pressure, for example in a patient having resistant hypertension, comprises administering such a dosage form once daily to the patient. |
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Bibliography: | Application Number: EP20070868665 |