Liposome composition of colistin for intravenous, oral, and cutaneous therapeutic use, and process for its preparation

For administration via intravenous route at higher dosages with greater clinical effectiveness, reaching higher tissue concentrations and without determining side effects at a renal level, colistin, a known bactericide against Gram-negative bacteria, is chemiadsorbed on a substrate of liposomes. The...

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Bibliographic Details
Main Authors TASCINI, GIOVANNI, TASCINI, CARLO
Format Patent
LanguageEnglish
French
German
Published 01.07.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:For administration via intravenous route at higher dosages with greater clinical effectiveness, reaching higher tissue concentrations and without determining side effects at a renal level, colistin, a known bactericide against Gram-negative bacteria, is chemiadsorbed on a substrate of liposomes. The liposome composition containing colistin that is obtained can be administered, via intravenous route or else in the form of syrup for oral use as intestinal decontaminant, whilst, in topical formulations such as creams or gels, it can be used in the treatment of skin infections or in prophylaxis of infections in patients affected by burns.
Bibliography:Application Number: EP20080172770