SITE-SPECIFIC INHIBITORS OF HISTONE METHYLTRANSFERASE [HMTASE] AND PROCESS OF PREPARATION THEREOF

The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1 and R1 is -OCH3 or -OH, R2 and R2 is -OH or -OAc; a process of isolating compound of structural formula Ia, where R1 and R1 is -OCH3, R2 and R2 is -OH; a process of p...

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Main Authors KEMPEGOWDA, MANTELINGU, VIKRU, RUTHROTHA, SELVI, BHARATHA, ANNAVARAPU, HARI, KISHORE, KUNDU, TAPAS, KUMAR
Format Patent
LanguageEnglish
French
German
Published 25.03.2009
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1 and R1 is -OCH3 or -OH, R2 and R2 is -OH or -OAc; a process of isolating compound of structural formula Ia, where R1 and R1 is -OCH3, R2 and R2 is -OH; a process of preparation of compound of structural formula Ib, where R1 and R1 is -OCH3, R2 and R2 is -OAc; a process of preparation of compound of structural formula Ic, where R1 and R1 is -OH, R2 and R2 is -OH; and use of compounds of structural formula I for manufacture of a medicament for management of cancer and/or disease conditions in a subject in need thereof.
Bibliography:Application Number: EP20070805629