SYNTHETIC PEPTIDES USED FOR TREATING THE SKIN AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS

• Main Authors: PUIG MONTIEL, ARTURO, CEBRIAN PUCHE, JOAN, CARREÑO SERRAIMA, CRISTINA, ALMIÑANA DOMENECH, NURIA, VAN DEN NEST, WILL, PASSERINI, ELENA
• Format: Patent
• Language: English; French; German
• Published: 07.01.2015
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The present invention relates to peptides of general formula (I) capable of regulating fibrillogenesis, stereoisomers thereof and mixtures thereof, which may or may not be racemic, and the cosmetically or dermopharmaceutically acceptable salts thereof, wherein Z is alanyl, allo -isoleucyl, glycyl, isoleucyl, isoseryl, isovalyl, leucyl, norleucyl, norvalyl, prolyl, seryl, threonyl, allo -threonyl or valyl; n and m may vary between 1 and 5; AA is selected from the group consisting of natural amino acids encoded in their L- or D- form and non-encoded amino acids; x and y may vary between 0 and 2; R 1 is H or alkyl, aryl, aralkyl or acyl group; and R 2 is amino, hydroxyl or thiol, all of them substituted or non-substituted with aliphatic or cyclic groups. A method for obtaining cosmetic or dermopharmaceutical compositions containing them and use thereof for treating the skin, preferably those skin conditions which require regulating fibrillogenesis, such as aging and/or the softening of the appearance of scars.