PHARMACEUTICAL COMPOSITION FOR CONFORMATIONAL DISEASE

• Main Author: DOHURA, KATSUMI
• Format: Patent
• Language: English; French; German
• Published: 21.01.2009
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

A pharmaceutical composition is provided which is prophylactically and/or therapeutically effective for a conformational disease typified by Alzheimer's disease, prion disease, and amyloidosis. The pharmaceutical composition of the present invention includes as an active ingredient one or more cellulose ethers selected from a cellulose ether having a structural unit represented by the general formula (1): in which at least one R is selected from CH 3 , C 2 H 5 , CH 2 CH 2 OH, CH 2 CH(OH)CH 3 , and CH 2 COOM; while other R is H; and M is selected from H, Na, K and Ca, an alkali metal salt of the cellulose ether, an aliphatic acid ester of the cellulose ether, and a mixture thereof.