A HOMOGENEOUS TIME RESOLVED FLUORESCENCE BASED TEST METHOD

The present invention concerns a fluorescence resonance energy transfer based high throughput test system to measure the formation of the HIV gp41 six-helix bundle. In a first embodiment the current invention relates to a homogeneous time resolved fluorescence-based test system comprising a first he...

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Bibliographic Details
Main Authors VEREYCKEN, INGE, VAN ACKER, KOENRAAD LODEWIJK AUGUST, GUSTIN, EMMANUEL MARIE PAUL ERNEST, OHAGEN, AASA CATRINE, DAMS, GERY KAREL JULIA, VERSCHUEREN, WIM GASTON
Format Patent
LanguageEnglish
French
German
Published 10.07.2013
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The present invention concerns a fluorescence resonance energy transfer based high throughput test system to measure the formation of the HIV gp41 six-helix bundle. In a first embodiment the current invention relates to a homogeneous time resolved fluorescence-based test system comprising a first helical polypeptide consisting essentially of the sequence of IQN36 (SEQ ID NO:1); a second helical polypeptide consisting essentially of the sequence of C34 (SEQ ID NO: 2) wherein said IQN36 is labeled with a light emitting fluorophore and said C34 is labeled with an ultra-violet excitable fluorophore.
Bibliography:Application Number: EP20070727885