Triazolyl tropane derivatives as CCR5 modulators
The present invention provides compounds of the formula: wherein R 1 is C 3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C 1-6 alkyl optionally substituted by one or more fluorine atoms, or C 3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
23.01.2013
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides compounds of the formula:
wherein R 1 is C 3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C 1-6 alkyl optionally substituted by one or more fluorine atoms, or C 3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and
R 2 is phenyl optionally substituted by one or more fluorine atoms,
pharmaceutically acceptable salts and solvates thereof, and processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds. In particular, the present invention provides polymorphs of N-{(1S)-3-[3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}-4,4-difluorocyclohexanecarboxamide |
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Bibliography: | Application Number: EP20080163025 |