MODIFIED MACROMOLECULE

The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a de...

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Main Authors KRIPPNER, Guy Yeoman, KARELLAS, Peter, PALLICH, Sue, BOYD, Benjamin James, PORTER, Christopher John Hamilton, KELLY, Brian Devlin, KAMINSKAS, Lisa Michelle, WU, Zemin, RAZZINO, Pasquale
Format Patent
LanguageEnglish
French
German
Published 02.11.2022
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Abstract The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
AbstractList The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
Author KAMINSKAS, Lisa Michelle
PORTER, Christopher John Hamilton
RAZZINO, Pasquale
PALLICH, Sue
KELLY, Brian Devlin
WU, Zemin
BOYD, Benjamin James
KARELLAS, Peter
KRIPPNER, Guy Yeoman
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– fullname: BOYD, Benjamin James
– fullname: PORTER, Christopher John Hamilton
– fullname: KELLY, Brian Devlin
– fullname: KAMINSKAS, Lisa Michelle
– fullname: WU, Zemin
– fullname: RAZZINO, Pasquale
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Snippet The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
Title MODIFIED MACROMOLECULE
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