Aromatic 1,4-DI-Carboxylamides and their use

• Main Authors: GARCIA, GABRIEL, LEMAILLET, GUY, FROESCH, BARBARA, SCAPOZZA, LEONARDO, DARAM, PIERRE
• Format: Patent
• Language: English; French; German
• Published: 18.06.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel compounds of formula I Wherein X, Y, Z represent independently from one another C or N, n stands for 1, 2, 3, m is 0 or 1, p stands for 0 or an integer from 1 to 6, R 1 , R 2 represent independently from one another hydrogen, a halogen atom, a hydroxyl group, a C 1 -C 3 alkyl group and a C 1 -C 3 alkoxy group, R 3 represents, independently from one another if p is not 0, hydrogen, halogen, a C 1 -C 5 linear or branched alkyl, a carboxylyl, a carbomethoxyl, carboethoxyl, a benzyl, an acyl, a hydroxyl, a C 1 -C 4 linear or branched alkoxyl, a trifluoromethyl, a cyano, a morpholino, a 1,3-dioxolyl, an N-acetylamidyl or an amidoyl group, a saturated 5-8 membered ring, a heterocyclic ring, optionally substituted by a C 1 -C 3 alkyl, a hydroxyl or a benzyl group, a C 1 -C 6 alkylsulfonyl, a mono or disubstituted C 1 -C 5 alkyl group, a branched or a cyclic amine, R 6 is H or part of a alicyclic,heteroalicyclic ring system, if m is 0 then C represents CF 3 or a branched or unbranched C 1 -C 4 alkyl group, if m = 1 then C represents -CH 2 -O-, -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, -CH 2 (CH 2 )CH 2 - or denotes a chemical bond between N-C or C-C, the CONR 6 group may be linked to C either via its carbon or via its nitrogen atom, CYC stands for a by R 3 substituted or unsubstituted phenyl, pyridinyl, naphthyl, quinolinyl, isoquinolinyl, isoxaxolinyl, thiophenyl, 1,3,4-thiadiazazolidinyl, furanyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, morpholinyl, furanyl, cyclohexenyl, and chromen-2-on-yl and its use as a medicament for the treatment of cancer.