QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT

The present invention provides compounds of Formula I (wherein X, m, R1, R2, R3, and R4 are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular prolifera...

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Bibliographic Details
Main Authors MALLAMS, ALAN K, VACCARO, HENRY, A, NEUSTADT, BERNARD, R, DASMAHAPATRA, BIMALENDU, DEMMA, MARK
Format Patent
LanguageEnglish
French
German
Published 28.05.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides compounds of Formula I (wherein X, m, R1, R2, R3, and R4 are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
Bibliography:Application Number: EP20060787068