A COMPOSITION COMPRISING AN EXTRACT OF TIARELL POLYPHYLLA AND TIARELLIC ACID ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY

• Main Authors: SHEN, GUANG HAI, KIM, GUN CHEOL, HAN, GYOON HEE, MIN, BYUNG SUN, QUAN, GUI HUA, KIM, DOO YOUNG, OH, SEI RYANG, PARK, HEA YOUNG, KWON, OK KYOUNG, PARK, BO YOUNG, KIM, MI JIN, LEE, HYEONG KYU, LEE, SAN KU, AHN, KYUNG SEOP, KIM, JOO HEON, KIM, SO YOUNG, CHOI, SOON JA, LEE, JOONG KU, KIM, JUNG HEE, KIM, EUN AH
• Format: Patent
• Language: English; French; German
• Published: 20.10.2010
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine(IL-4, IL-5 and IL- 13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.