N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activ...
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Main Author | |
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Format | Patent |
Language | English French German |
Published |
30.04.2008
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. The present invention also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial. |
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Bibliography: | Application Number: EP20070110559 |