A PROCESS FOR THE PREPARATION OF LOSARTAN DERIVATIVES BY CHLORINATION AND REDUCTION OF THE RESPECTIVE 1H-IMIDAZOLE-5-CARBALDEHYDES

The invention provides a process for the preparation of a sartan derivative of formula (I): wherein R = C2-C7 straight or branched alkyl or C3-C9 cycloalkyl, or a pharmaceutically acceptable salt thereof, comprising the steps of chlorinating and reducing, in any order, a compound of formula (III): w...

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Bibliographic Details
Main Authors PUTALA, MARTIN, VEVERKOVA, EVA, JORDAN, BERTA, KOTAR, VEVERKA, MIROSLAV, BARTOVIC, ALEXANDER, KRIZ, MIROSLAV
Format Patent
LanguageEnglish
French
German
Published 19.03.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a process for the preparation of a sartan derivative of formula (I): wherein R = C2-C7 straight or branched alkyl or C3-C9 cycloalkyl, or a pharmaceutically acceptable salt thereof, comprising the steps of chlorinating and reducing, in any order, a compound of formula (III): wherein R is defined as above to form a compound of formula (VI), wherein R is defined as above and then deprotecting said compound of formula (VI) to obtain the sartan derivative of formula (I), and optionally converting said sartan derivative into one of its pharmaceutically acceptable salts. A preferred embodiment of this invention is a process for the preparation of losartan and, particularly, its potassium salt.
Bibliography:Application Number: EP20060754522