Process for Producing Lercanidipine

A process for preparing 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2- [(3,3-diphenyl-propyl) methylamino]-1,1-dimethylethyl ester (Lercanidipine) I, which comprises reacting 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 1,1-dimethylethyl-2...

Full description

Saved in:
Bibliographic Details
Main Authors GARACZI, SANDOR, SZUECS, STEFANIA CSEREPI, LUKACS, FERENC, BERTOLINO, ANDREA, SCHNEIDER, GEZA, OROSZ, GYOERGY, BOR, ADAM
Format Patent
LanguageEnglish
French
German
Published 26.11.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:A process for preparing 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2- [(3,3-diphenyl-propyl) methylamino]-1,1-dimethylethyl ester (Lercanidipine) I, which comprises reacting 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 1,1-dimethylethyl-2-methylamino ethyl methyl ester IX or a salt thereof with a compound of the general formula L-O-CH 2 -CH 2 -CHPh 2 where L-O is a leaving group.
Bibliography:Application Number: EP20060114517