CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I...

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Main Authors CHEN, ZHAOGEN, MCCOWAN, JEFFERSON, RAY, SNYDER, NANCY, JUNE, WALLACE, OWEN, BRENDAN, CHICARELLI, MARK, JOSEPH, AICHER, THOMAS, D, HINKLIN, RONALD, JAY, ALLEN, JOHN GORDON, MABRY, THOMAS, EDWARD, WINNEROSKI, LEONARD, LARRY, JUNIOR, TIAN, HONGQI
Format Patent
LanguageEnglish
French
German
Published 18.07.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.
Bibliography:Application Number: EP20050819201