2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

• Main Authors: KHIRE, UDAY, BRENNAN, CATHERINE, KUMARASINGHE, ELLALAHEWAGE, HONG, ZHENQIU, WICKENS, PHILIP, KLUENDER, HAROLD, C, E, CHUANG, CHIH-YUAN, PHILLIPS, BARTON, WANG, LEI, DUMAS, JACQUES, KREIMAN, CHARLES, ENYEDY, ISTVAN, REDMAN, ANIKO, JONES, BENJAMIN, D, BIERER, DONALD, DIXON, JULIE, A, SCOTT, WILLIAM, J
• Format: Patent
• Language: English; French; German
• Published: 28.03.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.