N-(1-(1-BENZYL-4-PHENYL-1H-IMIDAZOL-2-YL)-2,2-DIMETHYLPROPYL)BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE PROTEIN (KSP) INHIBITORS FOR THE TREATMENT OF CANCER

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the followi...

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Main Authors RAMURTHY, SAVITHRI, PECCHI, SABINA, BARSANTI, PAUL, A, YANG, HONG, BAIR, KENNETH WALTER, WAYMAN, KELLY, JAZAN, ELISA, CONSTANTINE, RYAN, RAMA, JAIN, SABRAMANIAN, SHARADHA, SHARMA, ANU, BRAMMEIER, NATHAN, PHILLIPS, MEGAN, LAGNITON, LIANA, MARIE, WANG, WEIBO, BOYCE, RUSTUM, S, RENHOWE, PAUL, MIEULI, ELIZABETH, XI, YI, MENDENHALL, KRIS
Format Patent
LanguageEnglish
French
German
Published 27.02.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
Bibliography:Application Number: EP20050760871