ANTI-IL-13 ANTIBODIES, CRYSTALS OF ANTI-IL-13 ANTIBODIES AND OF COMPLEXES COMPRISING THEM

This application relates to antibodies, e.g ., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, prev...

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Main Authors LIN, LAURA, LONG, WILHELM, JAMES, M, SHANE, TANIA, PARRIS, KEVIN, D, HU, ZHIXIANG, DUMAS, JOHN, STAHL, MARK, TAN, XIANG-YANG, TAM, AMY, SZE, PUI, MOSYAK, LIDIA
Format Patent
LanguageEnglish
French
German
Published 28.02.2007
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This application relates to antibodies, e.g ., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders ( e.g., asthma); atopic disorders ( e.g ., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin ( e.g., atopic dermatitis), and gastrointestinal organs ( e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
Bibliography:Application Number: EP20050786816