Heterocyclic boronic acid derivatives, dipeptidyl peptidase IV inhibitors

Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH 2 ; S; O; CF 2 or C(CH 3 ) 2 ; Z is H; halogen; hydroxyl; (C 1-6 )alkoxy; (C 1-12 )alkyl; (C 3-12 )cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are option...

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Bibliographic Details
Main Authors CAMPBELL, DAVID ALAN, WINN, DAVID T
Format Patent
LanguageEnglish
French
German
Published 17.01.2007
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH 2 ; S; O; CF 2 or C(CH 3 ) 2 ; Z is H; halogen; hydroxyl; (C 1-6 )alkoxy; (C 1-12 )alkyl; (C 3-12 )cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R 7 ; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CR i R ii , R 1 , R 2 , R 3 , R 4 and R 5 are as described herein.
Bibliography:Application Number: EP20060015708