ACYL DIHYDRO PYRROLE DERIVATIVES AS HCV INHIBITORS

• Main Authors: SLATER, MARTIN JOHN, HAIGH, DAVID
• Format: Patent
• Language: English; French; German
• Published: 10.01.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel anti-viral agents of Formula (I) in which: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or C1-6alkyl optionally substituted by one or more substituents selected from halo, OR , SR , C(O)NR R , CO2H, C(O)R , CO2R , NR R , NHC(O)R , NHCO2R , NHC(O)NR R , SO2NR R , SO2R , nitro, cyano, aryl, heteroaryl and heterocyclyl; R represents hydrogen, C1-6alkyl, arylalkyl, or heteroarylalkyl; R and R are independently selected from hydrogen, C1-6alkyl, aryl and heteroaryl; or R and R together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R is selected from the group consisting of C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R and R are independently selected from the group consisting of hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or R and R together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; and J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.