FK228 ANALOGS AND THEIR USE AS HDAC-INHIBITORS
The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissues. In preferred embodiments, these analogs are characterized b...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
25.10.2006
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides FK228 analogs and methods of making and using the same. Such analogs are potent inhibitors of histone deacetylase and, in certain embodiments, are capable of specifically targeting cancerous cells and tissues. In preferred embodiments, these analogs are characterized by a cyclic disulfide design. |
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Bibliography: | Application Number: EP20040813928 |