SOLID IMPLANTS CONTAINING A BLOCK COPOLYMER FOR CONTROLLED RELEASE OF A GNRH COMPOUND

• Main Authors: GIBSON, JOHN, W, TIPTON, ARTHUR, J
• Format: Patent
• Language: English; French; German
• Published: 20.03.2013
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject. Preferred hydrophobic component is a PLG. Preferred hydrophilic Components are a PEG or a methoxyPEG. Preferred peptides are LHRH, goserelin, leuprolide.